鬼手神医云悠然为完成妈妈遗愿成为一代宗师，决定下山学习毒典。但毒典是顾氏传家之宝，只有嫁入顾家并生育子嗣才能学习，而顾泽正为养子的怪病寻鬼手神医。云悠然和顾泽因此协议结婚，历经种种误会终成眷属。
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人到中年的裴东明表面上是一个普通的保洁员，实际却是华国第一大公司的幕后掌权人，一次偶然的见义勇为与女儿闺蜜顾雪晴合力从混混手中救下了受欺负的少女。二人的缘分就此开启。
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本剧通过一个架空的“虚构世界”，讲述了这样一个故事，大夏镇国龙主萧云惨遭贱人陷害，家破人亡，为了寻找流落在外的妻子，辗转来到暗流涌动的江城，然而就在他想要带妻子一同回家之时，却遭到了妻子的拒绝，原来她
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楚家和沈家是当地的两大豪门巨头，近来媒体疯传楚家大小姐意外身亡的大新闻，与此同时，沈家失踪几天的大小姐沈秋禾突然回归了，重掌了沈氏家族。时间回到一年前，楚氏大小姐楚杉杉嫁给了一穷二白的凤凰男张一男，不
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乞丐乔岂为了当上皇帝去丞相府提亲，谁知丞相之女竟是青楼花魁，男主以一首《青花瓷》夺得花魁芳心！为了能够对抗镇南王，乔岂暗中建造工厂研发现代用品，镇南王派三百死侍包围丞相府，逼迫丐帮造反，乔岂将计就计最后不废一兵一卒夺得皇位！
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被人认为是收破烂乞丐的秦欢实际上有着另一重身份。机缘巧合下，叶家的家主发现了他是自己遗落在外的亲孙子。为了保护秦欢，他撮合了叶语涵和秦欢，希望他们相互扶持。一对欢喜冤家在磨合中渐渐擦出爱的火花，正当他们正要一起迎接新的生活时，秦欢的师父突然传来了急信……