医学博士李欣玥意外穿书，嫁给陈铭川。儿子高烧，婆婆阻拦就医，陈铭川提出离婚。真相大白后他反悔，李欣玥为给儿子治病历经波折，在制药厂被诬陷，她一次次化解危机，临盆难产时重回现代，与陈铭川重逢。
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叶子琪好心陪被老公家暴的闺蜜刘芸芸去旅游散心，男友李宇宁抢了一张下铺票给叶子琪，还告诉她不准和人换床。叶子琪以为男友心疼自己，所以在刘芸芸要求换床的时候拒绝了。结果刘芸芸半夜从上铺摔下来导致流产，把过错全赖在叶子琪头上，李宇宁也说叶子琪因为嫉妒，是故意的。叶子琪被刘芸芸老公张迟翰活生生掐死。叶子琪死后才知道，男友和闺蜜搞到一起，设局害她，她重生归来，决定以牙还牙！
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医圣叶梵受伤偶然成为赘婿，功力被封五年期间一直暗中帮助金家，觉醒后参加了五大家族举行的昆仑大会。叶梵作为一个不被众人看好的新人，最后狠狠打脸众人，向世界弘扬了医学精神。
10.0 全62集
民国14年，秦依晴的母亲顾文佩因撞破二姨太与管家奸情，和四姨太私下开娼妓馆的真相，被四姨太魏雪琴联合二姨太灭了口，秦依晴在亲眼目睹了母亲被杀害后，流落在外的她忍辱负重做了10年歌女，只为杀回秦家，报杀母之仇…
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林婉兮诞下女儿后被夫家嫌弃，吴氏设计害死招娣。林誓为女复仇，得丫鬟小月支持。丈夫新纳怀孕小妾杨秀珠，后者生下女儿亦被嫌弃，后与林婉兮产生姐妹情谊。林、杨与小月联手复仇，小月替林婉兮牺牲，林誓要报仇
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秦迎夏从初中时期开始暗恋靳酌七年，她拼尽全力考来帝大，只为能离他更近一点。开学时她拿错了行李箱，到宿舍打开后发现行李箱的主人竟然是靳酌。秦迎夏借机结识了帝大风云人物靳酌，两人在日渐相处中情愫暗生。
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海棠前世因拒绝给男主做妾，而被赵曼香折磨死。重生后海棠决定换一种活法，不但利用前世的记忆，用岁岁的小名引起男主盛怀瑾的注意，为进一步得到盛怀瑾的怜惜不惜以身入局，拿到了掌家之权，最终修成正果。
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为给妈妈治病，祝家女儿祝薇嫁给京州首富韩家大少爷韩澈，却在婚礼当天被躲避家族安排的韩澈抛下，好在婆婆林月清心善，为两人办好了结婚证。三年后祝薇一跃飞升成为熹微集团总裁，韩澈也回国。两人在无数次因工作合作的巧合事件中，韩澈渐渐被身边出色的祝薇吸引，但碍于自己隐婚的身份，他无奈压下了对她的情感。韩澈一边对自己的老婆“祝薇”厌恶至极，一边又对眼前的“祝薇”心生爱慕，弄出了不少闹剧。
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黎枝无数次梦到了同一个男人，两人在梦中夜夜缠绵无法摆脱，可是现实中的她却已经有了感情稳定的男朋友周楷。她与周楷的婚礼上遇到了梦中缠绵的男人，没想到那个男人竟然是当地只手遮天的大佬！还是周楷的小叔！
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赵雪和元元遭车祸，赵雪身亡，元元受伤昏迷。傅景笙却误以为赵雪是装病骗他，一心只想着带孙丽及她的宠物狗去看病。直到傅景笙亲眼看到病床上的元元，才得知赵雪已死的真相，后悔不已，将责任归咎于孙丽，赶走了她
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恋爱十周年纪念日，沈婷丢下男友林浩天的求婚，去陪初恋江槐，这件事成了林浩天决定跟沈婷分手的导火索。林浩天其实是首富家的儿子，为了和沈婷在一起，甘愿当个穷小子。林浩天当下便接受了家里安排的婚事，决定离开沈婷。沈婷和江槐假结婚的当天，林浩天跟首富千金顾瑶瑶就在隔壁厅结婚，沈婷懊悔不已，跪求林浩天回头。林浩天为了不让顾瑶瑶吃醋，上门找沈婷要房子车子，和沈婷彻底断干净。江槐婚后对沈婷并不好，沈婷后悔了。