无父无丹的孤儿易凡，学武成年后奉师父之命下山寻未婚妻沈小芸。不想却与已改名沈若芸的她发生意外，自此命运交织。此后，易凡为寻她战黑界、斗庸医、展医术，一路拼搏，终成江州市大人物，也如愿抱得美人归。
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叶宁临死前发现妻子李冰倩与奸夫卷走财产，更得知当年创业资金实为白月光宁瑶所赠，而宁瑶已因期货巨亏跳楼。重生回十年前，他火速报复李冰倩和奸夫，赶在宁瑶跳楼前找到她。虽劝阻平仓未果，但在宁瑶再被逼债时，叶宁用前世记忆三小时狂赚15亿还债。此后他屡次化解李冰倩的陷害，甚至预言战机公式成为院士。最终与宁瑶终成眷属，而李冰倩与奸夫落魄开餐馆，终日悔恨。
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陆前尘为了忙碌事业，不被催婚打扰，欺骗父母说自己有了妻女，早已成家。父母突然说要七天后到访，陆前尘为了不让自己的谎言被识破，和苏梦瑶组成临时夫妻，又到孤儿院选了一个懂事的5岁小女孩陆灵儿演自己的女儿
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琉光夫妻悉心培养女儿桑宁，让桑宁成为凤族最有可能涅槃的凤，而和桑宁一样大的丑奴却在被虐待中长大。在凤族的选拔大典上，关于桑宁和丑奴曾经被调换的事情被揭露，琉光却欣然同意换回女儿，并承认自己早就知情，在众人疑惑她为何这么狠心绝情时，琉光揭露了隐藏在这件事后更大的秘密。
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李小军生在一个巨富之家，而他却喜欢上了青梅竹马的女孩苏雪，并替苏雪挡下意外撞向她的车，医生本来宣布终生瘫痪，但李小军的母亲斥巨资找到世界顶级医疗团队，将李小军治好。为了检验苏雪对李小军的感情，李小军的母亲让李小军将计就计，装成瘫痪和苏雪继续交往。
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在山上修行的女主被师傅算出即将面对命劫，而霸总是他的气运之人，能帮他逆天改命，结果女主却误以为霸总是他的劫数于是想要下山教训他。
哪知霸总竟然是个恋爱脑，见了女主一面就喜欢上了女主，无脑维护女主把女主甜的不行，最后两人产生感情在一起。
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重生归来的林泽见到未婚妻徐若熙和她的白月光在酒吧亲密。第二天婚礼上，未婚妻借机暗暗表白白月光，被林泽戳穿，林泽彻底断绝和徐若熙之间的关系！这一世他不会选择忍让！
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沈碧春、沈明珠姐妹嫁入王府且同时有孕。沈碧春偷换孩子，沈明珠换回，可沈碧春不知，虐待亲儿荣长桦，偏爱荣长林。后太子选伴读，荣长桦遭沈碧春毁容，仍凭才学入选又被毁，荣长林当选。沈碧春争认子无果，幡然醒悟后自尽。最终沈明珠知晓孩子被换真相，状告荣毅仁，荣长桦挫败其叛国阴谋，荣毅仁入狱，一家人终团聚
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霍真珠是海晏有名的大慈善家、女企业家，在她生死垂危之际，儿媳孙清雅出现。此时霍真珠才得知，当初她袒护儿子霍友辰，将好儿媳关星月赶走，如今儿子霍友辰入狱，都是孙清雅一手策划，只为将她取而代之。霍真珠后悔不该赶走好儿媳，她发誓如有来生，一定要保护好好儿媳关星月，而当霍真珠再次醒来，她竟然回到了三年前。
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白寒梅，华夏顶尖中医，因学生孙玥排挤被迫离开任职的小医院。首富之子命危之际，她以九转须弥针震惊全场，仅收50元诊金。面对西医博士邓健对中医的偏见，她用疗效证明实力。当孙玥误诊导致血癌女孩垂危时，白寒梅再度力挽狂澜并研发出十元中药方，与邓健六十万天价特效药形成强烈对比。这场传统医术与现代医学的碰撞，揭开医者仁心与利益至上的终极较量。
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木清竹与阮瀚宇青梅竹马婚约在身，因乔安条陷害，阮瀚宇误会木清竹不检点而提商婚。木清竹为助其公司发展出国学汽车设计，回国却惊悉父母因阮氏豪车车祸离世，遂同意离婚，入职阮氏调查真相，最终解除误会破镜重圆