方时序活了千年，欲毁曾给他注射神秘基因药水害他的神秘组织。他与江氏集团总裁江知渺结缘生情，却又因他的秘密而误会。神秘组织来袭，江知渺与之携手历经危险。他们再次面对新的敌人和感情纠葛，是否能走出来呢.
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母亲知道儿子即将被爷爷拉去手术换皮，儿子这辈子将变得生不如死，她非但没有阻止，还嘱咐医生一定要执行手术，只因为上一世她成功阻止儿子落得这个下场，但是儿子却一直记恨她...
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都市白领杨天偶看短剧，吐槽后竟穿越其中，成为被羞辱的龙套男。为回归现实，他需击败四位拥有系统的男主。面对无脑开挂的对手，杨天凭借机智冷静，利用资源和剧情了解，逐一揭露神医、仙王、神豪、厨神系统的虚幻。他因此赢得女主们青睐。享受剧中生活的同时，杨天未忘现实。经艰难抉择，他决定带着剧中所得智慧与力量回归，继续书写传奇人生。杨天在异界斗智斗勇，终悟泡沫美好，毅然归途，以新得之力续写人生辉煌。
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一代传奇秦长安，化身乞丐在市井，帮助善良的人完成梦想。正值大夏财皇苏万三的大女儿苏冰凌得了疑难杂症，当世医道泰斗全部束手无策，此时苏雪娇路过拿着破碗的秦长安，便往碗里丢了些零钱，秦长安看出她的善良，于是随苏雪娇来到苏家救醒苏冰凌，苏万三为了报秦长安的救女之恩，决定招秦长安为女婿，并愿意赠送一半家产，但被秦长安婉拒……
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楚江宁与李红衣有婚约，楚江宁抗帝被处决后李红衣殉情。百年后楚江宁转世为楚天铭与白玫相恋，李红衣附身李婉茹害白玫。白玫穿越救楚天铭，李生元利用李婉茹被灭。最后白玫与李红衣同归于尽，李婉茹成族长。
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八岁的小草，失去父亲和奶奶，妈妈被卖去还债，一个人孤苦无依。村长的父亲赵建国，不忍小草流落在外，省吃俭用养大小草。小草考上大学，却被婶子撕毁入取通知书，把她嫁给隔壁村傻子。爷爷帮小草逃出赵家村，自己却被人打断了腿。
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快餐店老板周醒川免费供民工午餐三年，因回家办婚礼暂停三天，反遭抱怨与索赔。刘大海带头要求赔偿，周醒川停止供餐。刘大海因女婿顾宇峰关系升职，怒而砸店。顾宇峰现身，众人不信，张总盲目应承。周醒川揭露店内物品昂贵，众人殴打刘大海求原谅。警察证实后，众人下跪。刘大海出狱后投毒陷害，周醒川早有准备，将其抓获。最终，众人皆受惩罚。